High-accuracy neurite reconstruction for high-throughput neuroanatomy
نویسندگان
چکیده
منابع مشابه
High-throughput, high-accuracy array-based resequencing.
Although genomewide association studies have successfully identified associations of many common single-nucleotide polymorphisms (SNPs) with common diseases, the SNPs implicated so far account for only a small proportion of the genetic variability of tested diseases. It has been suggested that common diseases may often be caused by rare alleles missed by genomewide association studies. To ident...
متن کاملA Rapid, Inexpensive High Throughput Screen Method for Neurite Outgrowth
Neurite outgrowth assays are the most common phenotypic screen to assess chemical effects on neuronal cells. Current automated assays involve expensive equipment, lengthy sample preparation and handling, costly reagents and slow rates of data acquisition and analysis. We have developed a high throughput screen (HTS) for neurite outgrowth using a robust neuronal cell model coupled to fast and in...
متن کاملMUSCLE: multiple sequence alignment with high accuracy and high throughput.
We describe MUSCLE, a new computer program for creating multiple alignments of protein sequences. Elements of the algorithm include fast distance estimation using kmer counting, progressive alignment using a new profile function we call the log-expectation score, and refinement using tree-dependent restricted partitioning. The speed and accuracy of MUSCLE are compared with T-Coffee, MAFFT and C...
متن کاملBenchmarking Procedures for High-Throughput Context Specific Reconstruction Algorithms
Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool tailored to the analysis of specific individuals. The respective computational ...
متن کاملIterative Reconstruction Methods for High- Throughput PET Scanners
Iterative reconstructions for clinical PET must run fast. We describe a clinical processing method based on sinogram rebinning, Fourier rebinning for the 3D to 2D data reduction, and iterative reconstruction using the attenuation-weighted OSEM method with a projector based on a gaussian pixel model. When this approach is used, multi-bed clinical oncology scans can be ready for diagnosis within ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2011
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2868